解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Methoxetamine (MXE) is a chemical analogue of ketamine. Originally proposed as a ketamine-like fast-acting antidepressant, owing to similar N-methyl-D-aspartate blocker properties, it is now scheduled for reports of hallucinations and psychosis similar to ketamine and lysergic acid. As little is known about the addict...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000221
更新日期:2016-04-01 00:00:00
abstract::Impaired social interaction is a hallmark symptom of many psychiatric diseases, including dependence syndromes (substance use disorders). Helping the addict reorient her/his behavior away from the drug of abuse toward social interaction would be of considerable therapeutic benefit. To study the neural basis of such a ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000223
更新日期:2016-04-01 00:00:00
abstract::Some reports suggest that older patients are less responsive to antidepressants than young adults, but this idea has not been fully supported. Here, we investigated the role of aging in the behavioral effects of the antidepressants, desipramine (DMI) (5, 10, and 20 mg/kg) and fluoxetine (FLX) (5, 10, and 20 mg/kg) in ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000175
更新日期:2016-02-01 00:00:00
abstract::There is a considerable degree of individual vulnerability for alcohol use disorder (AUD) as only a subpopulation of individuals who regularly consume alcohol develop AUD. It is therefore very important to understand the factors and mechanisms that contribute towards the individual risk for AUD. In this respect, socia...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000165
更新日期:2015-10-01 00:00:00
abstract::Serotonin (5-hydroxytryptamine, 5-HT) is an important modulatory neurotransmitter and functions as a key neurodevelopmental signal in the mammalian brain. 5-HT plays a prominent role in regulating various types of psychological processes and functions, including mood and emotion, particularly anxiety, but also in regu...
journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/FBP.0000000000000172
更新日期:2015-09-01 00:00:00
abstract::The effects of RO-600175, a selective 5-HT2C receptor agonist, were studied in adult rats implanted for chronic sleep recordings. Intraperitoneal administration of RO-600175 (4 mg/kg) during the light phase of the light-dark cycle significantly increased wakefulness and reduced slow wave sleep and rapid-eye-movement s...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000142
更新日期:2015-08-01 00:00:00
abstract::Given the repeated failure of amyloid-based approaches in Alzheimer's disease, there is increasing interest in tau-based therapeutics. Although methylthioninium (MT) treatment was found to be beneficial in tau transgenic models, the brain concentrations required to inhibit tau aggregation in vivo are unknown. The comp...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000133
更新日期:2015-06-01 00:00:00
abstract::Evidence of observational learning (social learning) is present in many species. One such task is the one-trial taste-avoidance task, in which Actor chicks peck a bead coated with an aversant substance. Observer chicks learn to avoid beads that are similar in appearance to the one presented to the Actors. It has been ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000130
更新日期:2015-06-01 00:00:00
abstract::Appetitive behaviours occur in a state of behavioural and physiological activation that allows the optimal performance of these goal-directed behaviours. Here, we tested the hypothesis that histamine neurons under the command of the infralimbic cortex are important to provide behavioural activation. Extracellular hist...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000129
更新日期:2015-06-01 00:00:00
abstract::The brain endocannabinoid system is a potential target for the treatment of psychiatric and metabolic conditions. Here, a novel CB1 receptor antagonist (ABD459) was synthesized and assayed for pharmacological efficacy in vitro and for modulation of food consumption, vigilance staging and cortical electroencephalograph...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000108
更新日期:2015-04-01 00:00:00
abstract::Current concepts of basal ganglia function have evolved from the essentially motoric, to include a range of extramotoric functions that involve not only dopaminergic but also cholinergic, γ-aminobutyric acid (GABA)ergic and glutamatergic mechanisms. We consider these mechanisms and their efferent systems, including sp...
journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/FBP.0000000000000118
更新日期:2015-02-01 00:00:00
abstract::To investigate the role of the nucleus accumbens core (NAc) in the development of quinpirole-induced compulsive checking, rats received an excitotoxic lesion of NAc or sham lesion and were injected with quinpirole (0.5 mg/kg) or saline; development of checking behavior was monitored for 10 biweekly tests. The results ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000112
更新日期:2015-02-01 00:00:00
abstract::Flavonoids are natural substances obtained from plants. Most flavonoids cross the blood-brain barrier and exert a wide range of effects on the central nervous system. These actions have been attributed to the modulation of GABA-A receptors. Although motor systems in the central nervous system express a high density of...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000100
更新日期:2015-02-01 00:00:00
abstract::Methylphenidate (MPD) is clinically effective in treating the symptoms of attention-deficit hyperactivity disorder; however, its relatively widespread availability has raised public health concerns on nonmedical use of MPD among certain adult populations. Most preclinical studies investigate whether presumed therapeut...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000094
更新日期:2014-12-01 00:00:00
abstract::Male Syrian hamsters (Mesocricetus auratus) treated with anabolic/androgenic steroids (AAS) during adolescence (P27-P56) display highly escalated and mature forms of offensive aggression correlated with increased γ-aminobutyric acid (GABA) afferent development as well as decreased GABAA receptors in the lateroanterior...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000083
更新日期:2014-10-01 00:00:00
abstract::There is high comorbidity between depression and addiction. Features of addiction relevant to depression have been studied extensively, but less is known about features of depression relevant to addiction. Here, we have studied the effects of chronic mild stress (CMS), a valid animal model of depression, on measures o...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000046
更新日期:2014-09-01 00:00:00
abstract::Drug withdrawal is often conceptualized as an aversive state that motivates drug-seeking and drug-taking behaviors in humans. Stress is more difficult to define, but is also frequently associated with aversive states. Here we describe evidence for the simple theory that drug withdrawal is a stress-like state, on the b...
journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/FBP.0000000000000080
更新日期:2014-09-01 00:00:00
abstract::An individual's susceptibility to psychological and physical disorders associated with chronic stress exposure, for example, cardiovascular and infectious disease, may also be predicted by their reactivity to acute stress. One factor associated with both stress resilience and health outcomes is personality. An underst...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000064
更新日期:2014-09-01 00:00:00
abstract::Adolescence is one of the most important periods of brain development in mammals. There is increasing evidence that some medicines during this period can affect brain and behavioral functions in adulthood. Silymarin (SM), a mixture of flavonolignans extracted from the milk thistle Silybum marianum, is known as a hepat...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000051
更新日期:2014-08-01 00:00:00
abstract::The therapeutic potential of S1RA (E-52862), a selective sigma-1 receptor (σ1R) antagonist, has been explored in experimental neuropathic pain, but not in inflammatory pain models. The present study investigated the effect of the intraperitoneal administration of S1RA on the hind paw withdrawal response to thermal and...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000038
更新日期:2014-06-01 00:00:00
abstract::Several allosteric modulators (AMs) of the CB1 receptor have been characterized in vitro, including Org27569, which enhances CB1-specific binding of [H]CP55,940, but behaves as an insurmountable CB1-receptor antagonist in several biochemical assays. Although a growing body of research has investigated the molecular ac...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000027
更新日期:2014-04-01 00:00:00
abstract::Cannabinoid receptor (CBR) agonists produce antinociception in conventional preclinical assays of pain-stimulated behavior but are not effective in preclinical assays of pain-depressed behavior. Fatty acid amide hydrolase (FAAH) inhibitors increase physiological levels of the endocannabinoid anandamide, which may conf...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000023
更新日期:2014-04-01 00:00:00
abstract::We recently developed a procedure to study fear incubation, in which rats given 100 tone-shock pairings over 10 days show low fear 2 days after conditioned fear training and high fear after 30 days. Notably, fear 2 days after 10 sessions of fear conditioning is lower than fear seen 2 days after a single session of fea...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000020
更新日期:2014-02-01 00:00:00
abstract::Dopamine receptors are implicated in the reinforcing effects of food and drug reinforcement. The purpose of this study was to evaluate whether blocking D2 dopamine receptors during extinction (secondary reinforcement) would affect reacquisition of responding for food pellets (primary reinforcement). Food-restricted ra...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000002
更新日期:2013-12-01 00:00:00
abstract::In the present study, we focused on γ-aminobutyric acid (GABA) signaling through the γ-aminobutyric acid transporter (GAT) in the developing rat cerebral cortex. Tiagabine was used as a GAT inhibitor. The offspring received injections from birth until postnatal day 21 intraperitoneally. Physical development and neurol...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e328365422f
更新日期:2013-10-01 00:00:00
abstract::Drug addiction is a progressive, relapsing disease comprised of interlocking stages of disordered motivation. Numerous animal models describing various stages of the addiction process have been developed over the past few decades, providing considerable advantages for the modeling of drug addiction compared with other...
journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/FBP.0b013e3283644d15
更新日期:2013-09-01 00:00:00
abstract::Scopolamine has been used in neuropsychopharmacology as a standard drug that leads to symptoms mimicking cognitive deficits seen during the aging process in healthy humans and animals. Scopolamine is known to be a nonselective muscarinic receptor blocker, but its chronic effect on the expression of certain hippocampal...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32835a38af
更新日期:2012-12-01 00:00:00
abstract::The cannabinoid receptor agonist Δ(9)-tetrahydrocannabinol (THC) enhances the antinociceptive effects of µ-opioid receptor agonists, raising the possibility of using a combination of THC and opioids for treating pain. This study examined the effects of noncontingent and contingent administration of THC on intravenous ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32835a3907
更新日期:2012-12-01 00:00:00
abstract::Baclofen has shown promise in treating substance use disorders and also reduced binge frequency in an open-label trial. This placebo-controlled, double-blind, crossover study further assessed the effects of baclofen on binge eating. Twelve individuals who self-reported binge eating completed the study. Data were colle...
journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/FBP.0b013e328357bd62
更新日期:2012-09-01 00:00:00
abstract::This study evaluated the effect of intermittent administration in the development of dependence to diazepam in chronic use of the drug. Gabapentin was used to provide an anxiolytic effect on drug-free days. During a 28-day treatment schedule, rats were given diazepam (15 mg/kg) once daily continuously, or intermittent...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e3283512c6d
更新日期:2012-04-01 00:00:00
abstract::We have observed that, after myocardial infarction (MI), rats display apoptosis in the limbic system that can be prevented by pentoxifylline (PTX), a proinflammatory cytokine inhibitor. We have hypothesized that reduction of apoptosis in the limbic system can attenuate the depressive behaviour occurring post-MI. The p...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32834d1385
更新日期:2011-12-01 00:00:00
abstract::Cannabis is the most popular illicit drug used by adolescents. Yet, there are only a few studies that have examined the effects of cannabis use on learning and memory during this sensitive and important neurodevelopmental stage. Male adolescent Sprague-Dawley rats were treated with Δ(9)-tetrahydrocannabinol (THC, 6 mg...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32834dbbb1
更新日期:2011-12-01 00:00:00
abstract::Parkinson's disease psychosis (PDP) is a condition for which a safe, tolerated, and effective therapy is lacking. Treatment with typical or atypical antipsychotics may be contraindicated in patients with PDP because of the potential for aggravating motor symptoms. This study used a novel animal model with features of ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32834aff98
更新日期:2011-10-01 00:00:00
abstract::In light of the adverse side-effects of opioids, cannabinoid receptor agonists may provide an effective alternative for the treatment of cancer pain. This study examined the potency and efficacy of synthetic CB1 and CB2 receptor agonists in a murine model of tumor pain. Intraplantar injection of the CB1 receptor agoni...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e3283474a6d
更新日期:2011-09-01 00:00:00
abstract::There is accumulating evidence that sex plays a critical role in drug abuse. Female sex hormones have been shown to affect central nervous system function and modulate the effects of drugs of abuse. For example, γ-aminobutyric acid type A (GABA(A)) receptor function is positively modulated by progesterone metabolites....
journal_title:Behavioural pharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1097/FBP.0b013e328349fc02
更新日期:2011-09-01 00:00:00
abstract::This study compared fixed-ratio (FR) and fixed-interval (FI) schedules to investigate the discriminative stimulus properties of μ-opioid and/or κ-opioid receptor agonists. Pigeons were trained to discriminate among morphine (μ agonist), U50488 (κ agonist), the combination, and saline under FR 20-s or FI-300-s schedule...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e328349ab6c
更新日期:2011-09-01 00:00:00
abstract::The acute and chronic effects of certain drugs can often be opposite. For example, in congestive heart failure acute administration of β-adrenoceptor agonists results in beneficial improvement in symptoms of the disease, but their chronic use increases mortality. Conversely, certain β-adrenoceptor antagonists/inverse ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/FBP.0b013e328348ec6f
更新日期:2011-09-01 00:00:00
abstract::The aim of this study was to investigate the effects of a mixed dietary intervention on behavioral symptoms in serotonin transporter knockout (5-HTT⁻/⁻) rats modeling the human 5-HTT length polymorphic region short-allele. Twenty female 5-HTT⁻/⁻ and 19 wild-type (5-HTT⁺/⁺) rats were fed for 3 months on a mixed polyuns...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e328347881b
更新日期:2011-08-01 00:00:00
abstract::Obesity and cigarette smoking are often cited separately as the top two preventable causes of death in the United States; however, little research has explored the factors associated with being both obese and a smoker. Delay discounting is a behavioral characteristic that may underlie both of these conditions/behavior...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e328345c855
更新日期:2011-06-01 00:00:00
abstract::Drug-related stimuli seem to contribute to the persistence of drug seeking and relapse. Behavioral momentum theory is a framework for understanding how the discriminative-stimulus context in which operant behavior occurs governs the persistence of that behavior. The theory suggests that both resistance to change and r...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e328341e9fb
更新日期:2011-02-01 00:00:00